History and Mission of IRE

Scientific Institute for Research, Hospitalization and Care (IRCCS) since 1939
The Regina Elena National Cancer Institute (IRE) is actively involved in three main areas: clinical, research and training. Its mission is to achieve excellence in the prevention, diagnosis and treatment of cancer through research in the fields of epidemiology, etiology, and neoplastic transformation and progression of experimental therapies.
The Institute bases its activities on core values which include: reliability, putting the individual first, effectiveness and efficiency.
IRE’s forte lies in the synergistic combination and integration between the clinical and experimental research activities. Over time IRE has consolidated the strategic objective of enhancing translational research toward improving diagnosis and treatment in oncology.
IRE’s organizational framework is interdepartmental: various areas of expertise across different diagnosis and treatment sectors adopting a multidisciplinary approach benefitting patients, thus optimizing and integrating prevention, early diagnosis and therapy.
In order to promote the synergistic combination between basic and clinical research and pursue a more efficient transfer of knowledge and findings to the bedside table, the Scientific Officer set up six Translational Research Groups (TG) in 2013, dividing the groups into different areas of cancer including: lung, ovarian, urological, colorectal, brain and sarcomas cancers.
Fostering the increase of translational research has been achieved through the acquisition of sophisticated technology platforms, the use of acquiring appropriately equipped new space and the selection of highly skilled and qualified researchers.
The area of experimental research is dedicated to studying metabolic and molecular networks responsible for the formation and progression of tumors, their role in resistance to conventional therapies and overcoming resistance with targeted therapy (also known as "smart drugs") .
Oncogenomics, epigenetics, molecular oncology and imaging are among the tools primarily used to analyze gene expression profiles and to identify targets for intelligent therapies.
IRE was the first institute to introduce in surgery the use of perfusion, laparoscopy and robotics for increasingly conservative operations as well as dedicated to optimizing robotic techniques in all areas.
Other clinical research activities include personalized treatments of tumors, the control of cancer pain and the chrono-modulated chemotherapy, and new "intelligent drugs.
Some diagnostic and therapeutic services such as Nuclear Medicine, PET and radiotherapy are among the most modern and advanced in the European healthcare system.
IRE offers innovative care models such as activities on prevention and home care.
A Skeletal Muscle Tissue Bank has recently been set up, the only one located in the center south of Italy. Multidisciplinary Units have also been established such as: Sarcoma Unit, HPV Unit and Breast Unit.
At the Regina Elena Institute diagnostic and therapeutic pathways have been established, which are codified and shared by all clinicians. In this way, our medical professionals are up-to-date with the latest diagnostic and therapeutic services on a national and international level. Various medical professionals at our Institute closely collaborate with scientific associations & organizations that are involved in defining guidelines and policy directives to be applied in the medical and clinical practice nationwide.
IRE handles over one million outpatients each year, and more than 10.000 hospital admissions. It is also the regional referral center for digestive endoscopy, familial polyposis, multiple sclerosis and home care for neurosurgical patients as well as the national reference center for epilepsy and tumor patients.
IRE has greatly contributed both actively and culturally to numerous tasks and interventions commissioned by the Ministry of Health and the Region. It successfully participated in the regional project critical plan aiming to cut the hospital waiting lists down by providing 1884 more medical exams including MRIs, CTs, Ultrasounds, PETs and radiotherapies. IRE is a part of the Regional Oncology Commission, focusing its attention primarily on primary prevention of all cancers and screenings for cervical cancer, breast cancer, colorectal cancer and melanoma, together with defining diagnostic and therapeutic patient pathways as well as coordinating the oncology network in the region of Lazio.
IRE is a member of the Union for International Cancer Control (UICC), the Organization of European Cancer Institutes (OECI) and the European Organization for Research and Treatment of Cancer (EORTC - Early ClinicaI Trial Group). It also collaborates with a number of renowned international organizations such as the MD Anderson Cancer Center.

 IRE's 75 th Anniversary

The National Cancer Institute Regina Elena (IRE) was inaugurated on 21st April 1933 in Rome, after a few years it was recognized as the Research Institute of Hospitalization and Care (IRCCS). Since then, its main goal has been to achieve excellence in science, clinical basic and transactional research as well as in the organization and management of health care services always keeping the individual first.
On its 75th Anniversary, 21st April 2008, the Regina Elena Institute celebrated by presenting its latest innovation in the clinical field at the time: a biomolecular diagnostic technique for diagnosing breast cancer, one of its kind in Italy. It was announce by Prof. Giuseppe Petrella, President of the Board of Trustees and Verification IFO and was then later commented by the guest of honor Prof. Umberto Veronesi at the Lecture "Future prospects of biomedical research in Italy".
The President of the Regione Lazio, Piero Marrazzo, also joined in the celebration togther with the Minister of Health, Livia Turchio and numerous representatives of the Institute including: Sen. Joseph Ciarrapico, Sen. Cesare Cursi, Sen. Domenico Gramazio, Sen. Teresa Armed, Dr . Giovanni Zotta, Hon. Augusto Battaglia, Dr. Esterino Montino, Dr. Luigi Canali, Prof. Alessandro Finazzi Agro, Prof. Renato Guarini, Prof. Vincenzo Ziparo, Prof. Luigi Frati, Dr. Michele Svidercoschi, Prof. Renato Guarini, Prof. Renato Lauro, Prof. Enrico Graci, Dr. Claudio Clini.
During the celebration a video was shown briefly summarizing the steps taken by the Institute over the years as well as its many scientific achievements.