The mission of the SAFU UOSD focuses on the establishment of innovative mouse models of human cancer including implantation of tumor specimens into immunocompromised mice at the heterotopic and orthotopic sites and genetically engineered mouse models. All mouse models are devoted to study cancer initiation, immune system roles, tumor angiogenesis, environmental carcinogenesis, invasion as well as response to novel anticancer strategy. Currently, several models are being designed to allow in vivo imaging of tumor development from earlier stages and to follow tumor response to therapeutics. Besides to the research activities, this UOSD has the responsibility for day-to-day management of the Institute animal house. In agreement, this structure coordinates the activity of Animal Welfare Body (D.Lgs. n.26/2014), evaluating scientific projects in which are involved animal experimentations.
A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP.
Maurizio Fanciulli (PhD, Staff Scientist) 06/5266-2800